Apero Talks

The JSM3 AperoTalks are intended as informal and educational scientific presentations especially for all the students and young researchers of the IM2B. Everybody can present their research topic in a small less than 30 minute presentation in order to spark a scientific discussion.

After the lecture, there is an Apéro that allows everyone to share ideas & opinions, form networks and friendships with other students, either by just having a beer or by other themed-nights, such as games nights or similiar events.

The JSM3 2021/22 committee has relaunched the AperoTalks leading up to the JSM3 2022 conference on the 04. to 06. of May 2022.

AperoTalk special : 14.04.'22 at 6:00pm - New England Biolabs

Title: “What's New in Synthetic Biology?” (Sponsored AperoTalk)


New England Biolabs (NEB) is giving us the honor to visit the IM2B and talk to us about their newest products. NEB is a family-owned company leader in the discovery and production of efficient enzymes for molecular biology applications. NEB’s philosophy and most recents advances in Synthetic Biology will be presented as well as in the amplification and NGS fields.

This Aperotalk is actually going to be in the Amphithéâtre P. DESNUELLE on the CNRS Joseph Aiguier campus (where we will also have the congress in May !!!) and NOT in the Jacques Senez.

Exceptional INTER-Student ASSOCIATIONS event: 06 April 2022 - 7:00pm Baraka Jeux

Sixth AperoTalk : 01.04.'22 at 6:30pm - Luis Albero Macias Perez (BIAM)

Title: Microbial community colonization of a bauxite residue deposit marked by a complex geochemical context.


Bauxite residue is the byproduct generated during alumina extraction and is characterized by high levels of alkalinity, salinity, and toxic metals. Due to the absence of large-scale reuses, bauxite residues are commonly landfilled in open-air deposits that represent hostile environments for most domains of life. Techniques based on special microbial capabilities such as bioremediation or metal bio-extraction are now considered sustainable and cost-effective methods to revalorize bauxite residues. However, the establishment of microbial communities and their active role in these strategies are still poorly understood. We thus determine the geochemical composition of different bauxite residues produced in southern France by ICP-OES, ICP-MS and XRD analysis, and explore the development of bacterial and fungal communities using 16S and ITS metabarcoding, respectively. Taxonomical analysis revealed an early-stage microbial community dominated by haloalkaliphilic microorganisms and strongly influenced by chemical gradients. Microbial richness, diversity and network complexity increased significantly with the deposit age, reaching an equilibrium community composition similar to typical soils after decades of natural weathering. Our results suggested that salinity (EC), pH, and certain toxic metals (notably Cr and V) affected the bacterial community structure, while the fungal community composition showed no clear correlations with chemical variations.

If you have any questions about this talk or in general, please contact: jsm3@jsm3congress.fr

Fifth AperoTalk : 17.03.'22 at 6:00pm - Asma Hadjahmed (BIP)

Title: “Electrochemical cell design to controll mass transport”


Protein Film Electrochemistry (PFE) is a technique in which an enzyme is adsorbed at an electrode and its catalytic turnover rate is measured as an electrical current which allows the investigation of enzyme’s kinetics as a function of different experimental parameters. However, this technique requires fast transport of the substrate towards the electrode. In a previous study, our team proposed a new design based on the wall-tube electrode that provides better transport than the rotating disc electrode, which is commonly used in PFE methods. In this thesis, we explored, using computational fluid dynamics (CFD), the effect of the various parameters of the design and proposed semi-empirical formulas to predict the mass transport coefficient and shear stress at the electrode. We used a 3D-printed cell to validate experimentally our predictions. Moreover, we designed and built a new type of wall-tube electrodes with integrated mixers that should allow faster changes of substrate and inhibitor’s concentrations.

Due to the still ongoing Covid-pandemic the participation is limited and will be accompanied by ZOOM.

If you are interested, please contact: jsm3@jsm3congress.fr

Fourth AperoTalk : 09.03.'22 at 6:00pm - Boris Taillefer & Solène Beauvois (LISM)

Title: Type-6-Secretion System : from structure to evolution


The type VI secretion system (T6SS) is a toxin-delivering contractile nanoweapon used by bacteria to compete with each other in a contact-dependent manner. The T6SS structure is well known but variations in its components and its deployment exist in the bacterial diversity. Using complementary approaches (biochemistry, microscopy, genetics), our thesis work focused on the T6SS specificities of entero-aggregative Escherichia coli: its structure, dynamic, regulation and evolution. We will start that presentation with Solène Beauvois who will talk about the structure of that bacterial nanomachine, and molecular mechanisms implicated in toxin secretion into target bacteria. We will continue with Boris Taillefer who will give us the geneticist point of view and talk about the regulatory processes that allow the activation of the system in bacterial communities.

Due to the still ongoing Covid-pandemic the participation is limited and will be accompanied by ZOOM.

After the AperoTalk, Marie Grandjean will present her challenges in developing a card game on your favorite research area.

Serious games are now recognized educational tools that allow general public to discover science through a playful approach. Since 2017, my association has developed a card game called Microbioworld to make people aware of the fascinating complexity of the microbial world around them. During that short talk, I’ll focus on two questions : what are the key steps to create that kind of game? How to make the balance between science and gameplay?

AperoTalk special : 24.02.'22 at 5:00pm - AlphaFold Discussion

Title: "AlphaFold - a milestone in structural biology"


For more than 1 year after the results of the CASP14 in December 2020, Google’s DeepMind AlphaFold algorithm, which seems to accurately predict the three-dimensional structure of almost every protein, has been in various scientific discussions. This exciting scientific milestone is thanks again to Deep Learning applications in the field of life sciences and already is accelerating scientific progress.

But how does it work? Why is it a big deal? What are the key ideas behind the algorithm? And how can I use it in my everyday research?

All these questions we would like to address in a slightly different JSM3 AperoTalk on the 24.02.22 at 17 h in the Jacques Senez lecture hall on the CNRS campus.

Due to the still ongoing Covid-pandemic the participation is limited and will be accompanied by ZOOM.

If you are interested, please contact: jsm3@jsm3congress.fr

The presentation slides of that special AperoTalk can be found here:


Second AperoTalk : 27.01.'22 at 6:30pm - Subhadeep Chowdhury (MIO)

Title: "Diazotroph community and activity in the Southern Indian Ocean"


Dinitrogen (N2) fixers (diazotrophs) fuel primary productivity by providing reactive nitrogen into the ocean ecosystem and promoting CO2 sequestration. N2 fixation has been extensively studied in the low latitudes of the Atlantic and Pacific Oceans. By comparison, the Indian Ocean remains the least explored and most enigmatic ocean basin. This is particularly the case for the Southern Indian Ocean (SIO). Here we explore N2 fixation activity and diazotroph community composition, diversity and abundance from 20 to 60ºS in the SIO. While this region plays a key biogeochemical role serving as a link between the Atlantic and South Pacific Ocean waters, its N2 fixation potential remains unknown. Our results provide new insights into diazotrophy in a poorly studied region, and expand the range of biomes where diazotrophy may be observed.

First AperoTalk : 08.12.'21 at 5:30 pm - Romain Avellan (LISM)

Title: "New selective inhibitors for deciphering lipid metabolism in Mycobacterium tuberculosis"


Nowadays tuberculosis is still one of the leading causes of death by infectious disease worldwide, and the existence of numerous multi or totally drug resistant strains lead to a constant search for new antibiotics and new therapeutic targets to treat this infection. In this regard, mycobacterial lipolytic enzymes represent an important source of new therapeutic targets because they play key roles in mycobacterial envelope synthesis, growth, virulence and also in lipid droplet accumulation and consummation. In order to decipher Mycobacterium tuberculosis (M.tb) lipid metabolism, two family of new selective inhibitor targeting serine and cysteine hydrolases are used in my project: Oxadiazolone core derivatives (OX) and Cyclipostins/Cyclophostine derivatives (CyC). Indeed, those inhibitors have been modified through the addition of a terminal alkyne group to allow their labelling either with a fluorophore group to study their penetration and repartition in bacteria end host cells or with an enrichment group such as biotin to purify and identify inhibitor targets during the active growth, lipid accumulation and consumption in M.tb.